Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli
Michael G Napolitano, Matthieu Landon, Christopher J. Gregg, Marc J Lajoie, Lakshmi N. Govindarajan, Joshua A. Mosberg, Gleb Kuznetsov, Daniel B. Goodman, Oscar Vargas-Rodriguez, Farren J. Isaacs, Dieter Söll, George M. Church
The paper replaces rare arginine codons in E. coli with synonymous alternatives, identifying rules for codon choice based on mRNA structure and ribosomal binding motifs.
bioRxiv · Aug 14, 2016Genomics