George M. Church

This study uses single-cell sequencing to analyze T cell receptor pairing, finding non-random β chain associations and public clone sharing, which reduce T cell repertoire diversity.

The paper introduces a Cas9-based method to create and functionally profile eukaryotic DNA variant libraries, enabling efficient analysis of genetic alterations.

The paper constructs functional synthetic 30S ribosomal subunits in vitro and reports their efficiency and component requirements.

The paper develops a single-cell barcoding method to capture immune receptor sequences from tumor-infiltrating lymphocytes without sorting or culturing, demonstrating its application on ovarian cancer samples.

This study demonstrates that Elongation Factor P facilitates the ribosomal incorporation of consecutive D-amino acids by resolving peptidyl transferase stalling.

This study reprograms DYRK1A kinase specificity through synthetic mutations to mimic CK II substrate preferences, establishing a high-resolution specificity model.

This paper introduces CAGE 2.0, a platform for scarless assembly of recoded E. coli genome segments, enabling efficient and safe genome engineering.

The paper replaces rare arginine codons in E. coli with synonymous alternatives, identifying rules for codon choice based on mRNA structure and ribosomal binding motifs.

CasFinder identifies specific Cas9 target sites in genomes with low off-targeting potential, generating exome-wide catalogs for human and mouse for three Cas9 variants.

The paper evaluates the cost and performance of different connectomics strategies for whole mouse brain mapping, identifying potential cost reductions with emerging technologies.