Author

Christopher J. Gregg

Harvard UniversityPrimary ORCID profile (0000-0003-0819-1174 · 6 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Christopher J. GreggiD6 papers · University of Utah

Biology Disciplines

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Synthetic Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:E. coli· 2 Organism:bacteria (other)· 1 Assay:DNA methylation· 1 Research Focus:genome assembly· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

George M. Church· 2 shared Alexandra GonzalesiD· 1 shared Anik Debnath· 1 shared Barry L. Wanner· 1 shared Cameron L. GardneriD· 1 shared Conor K. CamplissoniD· 1 shared Daniel B. Goodman· 1 shared David K. Barclay· 1 shared

Activity by Year

2016-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersSynthetic Biology

George M. Church

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Author profile →

3 papers

Recent·Most cited

Characterizing the portability of RecT-mediated oligonucleotide recombination

Gabriel T. Filsinger, Timothy M. Wannier, Felix Boel Pedersen, Isaac D. Lutz, Julie Zhang, Devon A. Stork, Anik Debnath, Kevin Gozzi, Helene Kuchwara, Verena Volf, Stan Wang, Xavier Rios, Christopher J. Gregg, Marc J. Lajoie, Seth L. Shipman, , George McDonald Church

This study investigates the portability of RecT-mediated homologous recombination across bacterial species, finding that compatibility with the host's single-stranded DNA-binding protein determines functionality.

bioRxiv · Apr 14, 2020 · PreprintSynthetic Biology

Assembly of Radically Recoded E. coli Genome Segments

Julie E. Norville, Cameron L. Gardner, Eduardo Aponte, Conor K. Camplisson, Alexandra Gonzales, David K. Barclay, Katerina A. Turner, Victoria Longe, Maria Mincheva, Jun Teramoto, Kento Tominaga, Ryota Sugimoto, James E. DiCarlo, Marc Guell, Eriona Hysolli, , George M. Church

This paper introduces CAGE 2.0, a platform for scarless assembly of recoded E. coli genome segments, enabling efficient and safe genome engineering.

bioRxiv · Aug 31, 2016 · PreprintSynthetic Biology

Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli

Michael G Napolitano, Matthieu Landon, Christopher J. Gregg, Marc J Lajoie, Lakshmi N. Govindarajan, Joshua A. Mosberg, Gleb Kuznetsov, Daniel B. Goodman, Oscar Vargas-Rodriguez, Farren J. Isaacs, Dieter Söll, George M. Church

The paper replaces rare arginine codons in E. coli with synonymous alternatives, identifying rules for codon choice based on mRNA structure and ribosomal binding motifs.

bioRxiv · Aug 14, 2016Genomics