Bypass of Blocking Lesions by RNAPII Impairs the Transcriptional DNA Damage Response
Carolina P. Bañuelos, Lucas D. Caeiro, Pradeep Reddy Cingaram, Felipe Beckedorff, Lluís Morey, Daniel Bilbao Cortes, Ramin Shiekhattar, Ramiro E. Verdún
The paper shows that RNAPII bypassing DNA lesions, regulated by p300, leads to genome instability and reduced cell proliferation.
bioRxiv · Apr 28, 2025 · PreprintMolecular Biology