Pradeep Reddy Cingaram

A ncBAF to cBAF Switch Regulates Human Hematopoietic Progenitor Myeloid Differentiation

This study shows that BRD9 regulates myeloid differentiation in human HSPC by switching ncBAF to cBAF, leading to increased MDSC generation and IL-8 secretion.

Integrator governs NF-κB dwell time on chromatin to drive inflammatory transcription

This study identifies the Integrator complex as a key factor stabilizing NF-κB chromatin residence, essential for inflammatory gene activation in mouse and human cells.

The MLLT3 YEATS domain is a dual reader of histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking epigenetic and RNA signaling to regulate hematopoiesis

This study shows the MLLT3 YEATS domain binds both histone marks and the 7SK RNA, influencing hematopoietic lineage commitment and gene expression.

Enhancing Transcriptome Mapping with Rapid PRO-seq Profiling of Nascent RNA

This paper introduces rPRO-seq, a rapid PRO-seq method for nascent RNA profiling, and applies it to study Integrator's role in mouse hematopoietic stem cell homeostasis.

Bypass of Blocking Lesions by RNAPII Impairs the Transcriptional DNA Damage Response

The paper shows that RNAPII bypassing DNA lesions, regulated by p300, leads to genome instability and reduced cell proliferation.

The Integrator complex regulates microRNA abundance through RISC loading

This study shows that the Integrator complex is essential for miRNA abundance by facilitating their loading into RISC.