Ramin Shiekhattar

This study shows that BRD9 regulates myeloid differentiation in human HSPC by switching ncBAF to cBAF, leading to increased MDSC generation and IL-8 secretion.

This study identifies the Integrator complex as a key factor stabilizing NF-κB chromatin residence, essential for inflammatory gene activation in mouse and human cells.

This study identifies LSD1 as a cofactor of the menin-MLL-LEDGF complex and shows that combining menin and LSD1 inhibition effectively treats MLL-rearranged AML by dismantling oncogenic programs and promoting differentiation.

The paper shows that Corin, a dual LSD1/CoREST inhibitor, synergizes with ATRA to induce differentiation and apoptosis in AML by disrupting CoREST-RAR/RXR complexes and recruiting p300.

This study shows the MLLT3 YEATS domain binds both histone marks and the 7SK RNA, influencing hematopoietic lineage commitment and gene expression.

This paper introduces rPRO-seq, a rapid PRO-seq method for nascent RNA profiling, and applies it to study Integrator's role in mouse hematopoietic stem cell homeostasis.

The paper shows that RNAPII bypassing DNA lesions, regulated by p300, leads to genome instability and reduced cell proliferation.

The paper identifies the tetrameric INTS6-SOSS1 complex as essential for DNA:RNA hybrid autoregulation at double-strand breaks, facilitating DNA repair through PP2A recruitment and DARTs prevention.

This study shows that the Integrator complex is essential for miRNA abundance by facilitating their loading into RISC.