Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription.
Yongchuan Zhu, Min Huang, Eric A. Bushong, Sébastien Phan, Marco Uytiepo, Elizabeth Beutter, Daniel Boemer, Kristin CY Tsui, Mark H. Ellisman, Anton Maximov
This study shows that class IIa HDACs 4 and 5 regulate early response gene expression during learning, affecting memory formation and synaptic function.
Nature Communications · Aug 2, 2019Peer-reviewedNeuroscience