O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis
Sean A. Misek, Anna Borgenvik, Daniel Christen, Gloria Kyrila, Alexander Zhang, Sarah Martin Reel, Michelle Boisvert, Ke Xia Cai, Kevin Ning Zhou, Elizabeth Gonzáles, Amy B. Goodale, Lorena Lazo de la Vega, Timothy J. Ragnoni, Zohra Kalani, Nicole S. Persky, , Pratiti Bandopadhayay
The paper identifies O-mannosylation and protein maturation as therapeutic targets in BRAF fusion oncogenesis by showing their necessity for fusion-induced transformation.
bioRxiv · Aug 18, 2025 · PreprintCancer Biology