Author

Sean A. Misek

Broad InstituteORCID 0000-0002-0246-5018Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Rameen BeroukhimiD· 3 shared David E. RootiD· 2 shared Jason J. KwoniD· 2 shared William C. HahniD· 2 shared Aaron FultineeriD· 1 shared Adnan HalimiD· 1 shared Alexander Zhang· 1 shared Alexandra Larisa ConduratiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

Rameen BeroukhimORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 2, 2026

TangentXY: Improved copy-number estimation of sex chromosomes reveals features associated with aneuploidies in chromosomes X and Y across cancers

Kei Enomoto, Shahab Sarmashghi, Sean A. Misek…·Rameen Beroukhim

TangentXY improves copy-number estimation for sex chromosomes, revealing associations between chrX and chrY copy-number alterations and cancer features.

DOI 10.64898/2026.10.01.755972

humanwhole-genome sequencing

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Cancer BiologybioRxivPreprintAug 18, 2025

O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis

Sean A. Misek, Anna Borgenvik, Daniel Christen…·Pratiti Bandopadhayay

The paper identifies O-mannosylation and protein maturation as therapeutic targets in BRAF fusion oncogenesis by showing their necessity for fusion-induced transformation.

1 citation

humanproteomics

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Cancer BiologybioRxivPreprintOct 22, 2024

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

Jason J. Kwon, Julien Dilly, Shengwu Liu…·Andrew J. Aguirre

This study uses deep mutational scanning to analyze KRAS variants, identifying gain- and loss-of-function mechanisms and their impact on oncogenic activity.

13 citations

humanproteomics

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