Immune evasion and immunotherapy resistance via TGF-beta activation of extracellular matrix genes in cancer associated fibroblasts
Ankur Chakravarthy, Lubaba Khan, Nathan Peter Bensler, Pinaki Bose, Daniel D. De Carvalho
The paper identifies ECM gene dysregulation linked to TGF-beta in CAFs as a novel mechanism of immune evasion, predicting response to immune checkpoint blockade better than existing biomarkers.
bioRxiv · Feb 15, 2018 · PreprintCancer Biology