A microbiota membrane disrupter disseminates to the pancreas and increases β-cell mass
Jennifer Hampton Hill, Michelle Sconce Massaquoi, Emily Goers Sweeney, Elena S. Wall, Philip E. Jahl, Rickesha S. Bell, Karen Kallio, Daniel Derrick, Lewis Charles Murtaugh, R. Parthasarathy, S. James Remington, June L. Round, Karen J. Guillemin
This study identifies BefA, a microbiome-derived protein that promotes β-cell mass by permeabilizing membranes, linking microbiome composition to diabetes risk.
bioRxiv · Mar 24, 2022 · PreprintMolecular Biology