R. Parthasarathy

Social modulation of activity and orientation fosters complex interactions in young zebrafish

This study analyzes social behavior in young zebrafish, finding that they exhibit specific proximity preferences and turning biases that shape early social interactions.

Imaging the impact of rotifer consumption on bacterial behaviors in the zebrafish gut

This study uses live zebrafish larvae to observe how rotifer consumption alters the behavior of two gut bacteria, showing changes in motility and pathogenicity.

Characterizing trajectories of innate immune cells in larval zebrafish

This study tracks innate immune cell dynamics in larval zebrafish to show that gut structure, not microbial stimuli, primarily shapes immune cell movement patterns.

UV-irradiated rotifers for the maintenance of gnotobiotic zebrafish larvae

This study develops a method to maintain gnotobiotic zebrafish larvae by UV-irradiating rotifers, preserving pre-existing bacterial communities and enabling long-term microbiome studies.

Bacterial Modulation of Intestinal Motility through Macrophage Redistribution

This study shows that Vibrio cholerae's T6SS ACD induces intestinal contractions by activating macrophages and altering their distribution in zebrafish.

A microbiota membrane disrupter disseminates to the pancreas and increases β-cell mass

This study identifies BefA, a microbiome-derived protein that promotes β-cell mass by permeabilizing membranes, linking microbiome composition to diabetes risk.

Image velocimetry and spectral analysis enable quantitative characterization of larval zebrafish gut motility

The paper introduces an image analysis technique using image velocimetry and spectral analysis to quantify gut contraction strength, frequency, and wave speed in larval zebrafish.

Modernized tools for streamlined genetic manipulation of wild and diverse symbiotic bacteria

The paper develops genetic tools for manipulating symbiotic bacteria and uses them to study colonization patterns in zebrafish.