Additive effects on craniofacial development upon conditional ablation of PDGFRα and SHP2 in the mouse neural crest lineage
Daniel Fuhr, Jessica Johnston, Elliott P. Brooks, Katherine A. Fantauzzo
This study shows that conditional ablation of PDGFRα and SHP2 in mouse neural crest cells leads to craniofacial defects, with SHP2 regulating PDGFR signaling both positively and negatively.
Developmental Dynamics · Nov 17, 2025Peer-reviewedDevelopmental Biology