Intellectual disability-associated disruption of O-GlcNAcylation impairs neuronal development and cognitive function in Drosophila
Michaela Fencková, Villő Muha, Daniel Mariappa, Marica Catinozzi, Ignacy Czajewski, Laura E.R. Blok, Andrew T. Ferenbach, Erik Storkebaum, Annette Schenck, Daan M. F. van Aalten
This study shows that OGT mutations impair cognitive function in Drosophila by disrupting O-GlcNAcylation, and that blocking OGA can correct the deficit.
bioRxiv · Jan 10, 2022 · PreprintGenetics