Excessive ENaC-mediated sodium influx drives NLRP3 inflammasome-dependent autoinflammation in Cystic Fibrosis
Thomas Scambler, Heledd H. Jarosz-Griffiths, Samuel Lara-Reyna, Shelly Pathak, Chi Wong, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Daniel Peckham, Michael F. McDermott
This study shows that excessive ENaC-mediated sodium influx drives NLRP3 inflammasome-dependent autoinflammation in Cystic Fibrosis, with potential therapeutic implications for lung inflammation.
bioRxiv · Nov 6, 2018 · PreprintImmunology