A TRADE-OFF BETWEEN RESISTANCE TO INFECTION AND REPRODUCTION IN PRIMATE EVOLUTION
Sumnima Singh, Jessica A. Thompson, Sebastian Weis, Daniel Sobral, Mauro Truglio, Bahtiyar Yilmaz, Sofia Rebelo, Silvia Cardoso, Erida Gjini, Gabriel Nunez, Miguel P. Soares
The paper shows that loss of GGTA1 function in mice increases resistance to sepsis via enhanced IgG-Fc gamma receptor binding but causes earlier reproductive senescence, suggesting a trade-off that may explain primate evolution.
Cell Host & Microbe · Mar 1, 2021Peer-reviewedImmunology