Author

Sumnima Singh

Gulbenkian Institute for Molecular MedicineORCID 0000-0002-1826-0180Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Sebastian WeisiD· 2 shared Aarthi RamakrishnaniD· 1 shared Amanda K. FakiraiD· 1 shared Amni Al-KachakiD· 1 shared Ana Leonor FigueiredoiD· 1 shared Ana MiloseviciD· 1 shared Ana NóvoaiD· 1 shared Andrew F. StewartiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

Sebastian WeisORCID

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3 papers

Recent·Most cited

ZBTB7A regulates MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in orbitofrontal cortex

Sasha L. Fulton, Jaroslav M. Bendl, Giuseppina Di Salvo, John F. Fullard, Amni Al-Kachak, Ashley E. Lepack, Andrew F. Stewart, Sumnima Singh, Wolfram C. Poller, Ryan M. Bastle, Mads E. Hauberg, Amanda K. Fakira, Vishwendra Patel, Min Chen, Romain Durand-de Cuttoli, , Ian S. Maze

The paper identifies ZBTB7A as a key regulator of MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in the orbitofrontal cortex.

Neuron · Jun 13, 2025Peer-reviewedNeuroscience

Monocyte control of organismal energy homeostasis

Rui Martins, Birte Blankenhaus, Faouzi Braza, Pedro Ventura, Sumnima Singh, Sebastian Weis, Miguel Mesquita, Maria Pires, Sara Emanuela Pagnotta, Qian Wu, Sílvia Cardoso, Elisa Jentho, Ana Leonor Figueiredo, Pedro Faísca, Ana Nóvoa, , Miguel Parreira Soares

This study shows that monocyte-derived macrophages regulate energy homeostasis by responding to iron metabolism dysregulation in parenchyma cells.

bioRxiv · Feb 20, 2025 · PreprintImmunology

A TRADE-OFF BETWEEN RESISTANCE TO INFECTION AND REPRODUCTION IN PRIMATE EVOLUTION

Sumnima Singh, Jessica A. Thompson, Sebastian Weis, Daniel Sobral, Mauro Truglio, Bahtiyar Yilmaz, Sofia Rebelo, Silvia Cardoso, Erida Gjini, Gabriel Nunez, Miguel P. Soares

The paper shows that loss of GGTA1 function in mice increases resistance to sepsis via enhanced IgG-Fc gamma receptor binding but causes earlier reproductive senescence, suggesting a trade-off that may explain primate evolution.

Cell Host & Microbe · Mar 1, 2021Peer-reviewedImmunology