Mesenchymal Stromal Cell Therapeutic Potential to RestoreNeurovascular Integrity in Machado-Joseph Disease
Inês Barros, Daniela Gonzaga, Diana Lobo, Sara Lopes, Inês Morgado Martins, António Silva, Carina Henriques Silva, Célia M. F. Gomes, Rui Jorge Nobre, Luís Pereira de Almeida, Catarina Oliveira Miranda
This study evaluates the therapeutic potential of mesenchymal stromal cells (MSC) in mitigating vascular abnormalities and blood-brain barrier (BBB) disruption in Machado-Joseph disease (MJD) transgenic mice, showing partial restoration of vascular and BBB integrity.
bioRxiv · Feb 3, 2026 · PreprintNeuroscience