Sara Lopes

Nuclear aging in polyglutamine-induced neurodegeneration

This study investigates the role of aging in Machado-Joseph disease by analyzing age-related markers in human and animal models, finding decreased lamins and ZMPSTE24 levels and nuclear abnormalities.

Mesenchymal Stromal Cell Therapeutic Potential to RestoreNeurovascular Integrity in Machado-Joseph Disease

This study evaluates the therapeutic potential of mesenchymal stromal cells (MSC) in mitigating vascular abnormalities and blood-brain barrier (BBB) disruption in Machado-Joseph disease (MJD) transgenic mice, showing partial restoration of vascular and BBB integrity.

rAAV-Delivered Bicistronic Artificial microRNAs for Allele-Specific Silencing Improve Motor and Molecular Outcomes in Spinocerebellar Ataxia Type 3

This paper develops and tests rAAV-delivered bicistronic artificial microRNAs to selectively silence mutant ATXN3 in SCA3 mouse models, showing improved motor function and reduced mutant protein aggregates.

Circadian Rhythms are Disrupted in Patients and Preclinical Models of Machado-Joseph Disease

This study investigates circadian rhythm disruptions in Machado-Joseph disease patients and preclinical models, finding impaired clock gene expression and disrupted activity and temperature rhythms.