Experimental Human Challenge Reveals Distinct Mechanisms of Acquisition or Protection Against Pneumococcal Colonization
Elissavet Nikolaou, Simon P. Jochems, Elena Mitsi, Sherin Pojar, Edessa Negera, Jesús Reiné, Beatriz Carniel, Alessandra Soares-Schanoski, Victoria Connor, Hugh Adler, Seher Raza Zaidi, Caz Hales, Helen Hill, Angela Hyder-Wright, Stephen B. Gordon, , Daniela M. Ferreira
This study uses a human challenge model to show that nasal colonization by Streptococcus pneumoniae can take up to 24 hours and identifies two distinct clearance mechanisms involving neutrophils.
bioRxiv · Nov 5, 2018 · PreprintImmunology