Simon P. Jochems

Systematic Evaluation of Nasal Immune Cell Sampling and Antigen-specific T cell Detection using Cryopreserved Nasal Swabs

This study evaluates nasal immune cell sampling methods and antigen-specific T cell detection using cryopreserved nasal swabs, finding that flocked swabs yield more cells and cryopreservation preserves functional T cells.

Ageing of the Upper Airway Epithelial Niche Limits Tissue-Resident T Cell Immunity

This study shows that ageing reduces tissue-resident memory T cells in the upper airway, linked to impaired epithelial-immune crosstalk and reduced TGF-β signaling.

A cell surface proteomic atlas reveals socioeconomic status associated immune diversity

This study maps SES-related immune diversity using flow cytometry, finding lower SES associates with downregulated surface proteins and upregulated immune checkpoints.

Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses

The study uses spectral flow cytometry to analyze immune function across populations, revealing geographical differences and TLR8's role in mRNA vaccine responses.

Mass cytometry data integration methods reveal rural-urban gradient of immune profiles across geography

This study integrates mass cytometry data from diverse populations to identify immune signatures associated with rural living, finding shared differences in lymphocyte and innate immune cell characteristics.

Analysis and annotation of genome-wide DNA methylation patterns in two nonhuman primate species using the Infinium Human Methylation 450K and EPIC BeadChips

The paper evaluates and re-annotates DNA methylation probes from two microarrays for use in two nonhuman primate species, identifying reliable probes for high-throughput methylation analysis.

Experimental Human Challenge Reveals Distinct Mechanisms of Acquisition or Protection Against Pneumococcal Colonization

This study uses a human challenge model to show that nasal colonization by Streptococcus pneumoniae can take up to 24 hours and identifies two distinct clearance mechanisms involving neutrophils.