Targeting melanosome pH is an effective method for the treatment of oculocutaneous albinism
Samuel J. Grondin, Daniela St. Pierre, David J Green, Sidra Amir, Maftuna Yusupova, Joseph Bonica, Zuhal Eraslan, Tyler Wills, Callum Hunt, Dalee Zhou, Aman George, Jaewon You, Aditya Anandakumar, S S Gross, Ryan P. Schreiner, , Jonathan Hale Zippin
This study shows that reducing sAC activity restores pigmentation in OCA models and increases melanin synthesis, suggesting targeting melanosome pH as a therapeutic strategy for OCA and skin cancer risk.
bioRxiv · May 28, 2026 · PreprintPhysiology