Author

Samuel J. Grondin

Cornell University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Brian P. BrooksiD· 2 shared David R. AdamsiD· 2 shared Jonathan Hale ZippiniD· 2 shared Joseph Bonica· 2 shared Qiuying CheniD· 2 shared Stacie K. LoftusiD· 2 shared Zuhal EraslaniD· 2 shared Aditya Anandakumar· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Brian P. BrooksORCID

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Author profile →

2 papers

Recent·Most cited

Targeting melanosome pH is an effective method for the treatment of oculocutaneous albinism

Samuel J. Grondin, Daniela St. Pierre, David J Green, Sidra Amir, Maftuna Yusupova, Joseph Bonica, Zuhal Eraslan, Tyler Wills, Callum Hunt, Dalee Zhou, Aman George, Jaewon You, Aditya Anandakumar, S S Gross, Ryan P. Schreiner, , Jonathan Hale Zippin

This study shows that reducing sAC activity restores pigmentation in OCA models and increases melanin synthesis, suggesting targeting melanosome pH as a therapeutic strategy for OCA and skin cancer risk.

bioRxiv · May 28, 2026 · PreprintPhysiology

Ampyrone (4-Aminoantipyrine) is a Direct Agonist of Human Tyrosinase and Potential Therapeutic for Oculocutaneous Albinism and Disorders of Hypopigmentation.

Monika B. Dolinska, Yuhong Wang, Nathan P. Coussens, Vijay K. Kalaskar, Zuhal Eraslan, Samuel J. Grondin, Joseph Bonica, Sarah Toay, Matthew D. Hall, Min Shen, Matthew B. Boxer, Qiuying Chen, Steven S. Gross, Nabeel Attarwala, Yingyos Jittayasothorn, , Brian P. Brooks

The paper identifies ampyrone as a direct activator of human tyrosinase, showing increased catalytic activity and melanin synthesis in melanocytes and skin cultures, suggesting potential therapeutic use for hypopigmentation disorders.

bioRxiv · Oct 13, 2025 · PreprintPharmacology & Toxicology