The Drosophila cardiogenic transcription factors Myocyte enhancer factor-2 and Tinman contribute to heart lumen enlargement through direct activation of the collagen gene Multiplexin.
TyAnna L. Lovato, Danielle Ryan, Cayleen Bileckyj, Christopher A. Johnston, Richard M. Cripps
The paper identifies Mef2 and Tinman as regulators of heart lumen enlargement in Drosophila by activating the collagen gene Multiplexin.
bioRxiv · Jun 28, 2023 · PreprintDevelopmental Biology