Real-paired single-cell/bulk RNA-seq benchmark and a practical protocol for accurate cell-type deconvolution in human BAL samples
Yushan Hu, Ziying Liu, Danielle Tsao, Janice M. Leung, Firoozeh V. Gerayeli, Xuan Li, Xiaojian Shao, Don D. Sin, Xuekui Zhang
Systematic benchmarking reveals pseudo-bulk biases and provides practical fixes for accurate RNA deconvolution.
bioRxiv · Jan 14, 2026 · PreprintBioinformatics