Firoozeh V. Gerayeli

Systematic benchmarking reveals pseudo-bulk biases and provides practical fixes for accurate RNA deconvolution.

The paper constructs a standardized BAL scRNA-seq atlas using BAL-EA, a novel annotation framework, revealing disease-associated shifts in COPD and validating findings in COVID-19 datasets.

This study examines SARS-CoV-2 infection and repair responses in human airway epithelial cells, finding prolonged and incomplete repair linked to long-COVID pulmonary symptoms.

The paper develops a rapid, minimal-handling protocol for preparing single-cell suspensions from bronchial brush specimens for scRNA-seq to improve airway disease research.