Xuan Li

EnzCast predicts enzymatic kinetics from multi-modal data, and IsoKin infers patient-specific in vivo kinetics, showing improved uncertainty reduction in colorectal cancer.

Systematic benchmarking reveals pseudo-bulk biases and provides practical fixes for accurate RNA deconvolution.

The paper develops a rapid, minimal-handling protocol for preparing single-cell suspensions from bronchial brush specimens for scRNA-seq to improve airway disease research.

The paper uses multi-omics approaches to identify genes and plasma proteins associated with COVID-19, finding ABO plasma protein as a causal risk factor.

The paper identifies proteins associated with lung function and COPD risk using integrative omics and Mendelian Randomization, finding 37 proteins with causal associations.

The paper identifies co-expressed genes with ACE2 and TMPRSS2 in lung tissue and finds many have drug interactions, suggesting potential targets for COVID-19 therapeutics.

This study analyzes whole-genome sequencing data from 332 Chinese COVID-19 patients to identify genetic variants associated with disease severity and susceptibility.

This study uses Mendelian randomization to examine if ACE inhibitors or cardiometabolic risk factors affect lung ACE2 and TMPRSS2 expression or plasma ACE2 levels, finding no overall association.

This study uses Mendelian randomisation to show that higher serum CC-16 levels protect against COPD risk and progression, with genetic variants linked to CC-16 expression in lung tissue.

This study identifies three new genetic loci associated with idiopathic pulmonary fibrosis and confirms 11 previously reported ones, highlighting mTOR signaling and mitotic spindle-assembly genes in disease susceptibility.

The paper identifies 279 new genetic signals for lung function across multiple ancestries, showing associations with COPD and pleiotropic effects.