IL-6 is a Key Factor in the Formation of Gut Tissue Resident Memory T Cells from Naïve T cells
Han G. Kim, Amanda Chan, Sinmanus Vimopatranon, Alexandre Girard, Andrew Jiang, Samuel Wertz, Il‐Young Hwang, John H. Kehrl, Hana Schmeisser, Madelyn M Seemiller, Paolo Lusso, Dawei Huang, Danlan Wei, Livia Ramos Goes, Marcelo Alves Soares, , Claudia Cicala
This study identifies IL-6 as a key factor in the differentiation of naive CD4+ T cells into gut tissue resident memory T cells (TRMs) through a combination of MAdCAM-1, TGF-β, and RA signaling.
PLoS Pathogens · Mar 16, 2026Peer-reviewedImmunology