Author

Paolo Lusso

National Institute of Allergy and Infectious DiseasesORCID 0000-0002-2813-4081Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Abdolrahim Abbasi· 1 shared Alexandre GirardiD· 1 shared Alicia SatoiD· 1 shared Alonso HerediaiD· 1 shared Amanda Chan· 1 shared Andrew Asakawa· 1 shared Andrew JiangiD· 1 shared Anthony L. DeVico· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioengineering

Abdolrahim Abbasi

Mutual co-authors in cluster

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2 papers

Recent·Most cited

IL-6 is a Key Factor in the Formation of Gut Tissue Resident Memory T Cells from Naïve T cells

Han G. Kim, Amanda Chan, Sinmanus Vimopatranon, Alexandre Girard, Andrew Jiang, Samuel Wertz, Il‐Young Hwang, John H. Kehrl, Hana Schmeisser, Madelyn M Seemiller, Paolo Lusso, Dawei Huang, Danlan Wei, Livia Ramos Goes, Marcelo Alves Soares, , Claudia Cicala

This study identifies IL-6 as a key factor in the differentiation of naive CD4+ T cells into gut tissue resident memory T cells (TRMs) through a combination of MAdCAM-1, TGF-β, and RA signaling.

PLoS Pathogens · Mar 16, 2026Peer-reviewedImmunology

A Comprehensive Engineering Strategy Improves Potency and Manufacturability of a Near Pan-neutralizing Antibody Against HIV

Mohammad M. Sajadi, Abdolrahim Abbasi, Zahra Rikhtegaran Tehrani, Christine C. Siska, Rutilio H. Clark, Woo Chi, Michael S. Seaman, Dieter Mielke, Kshitij Wagh, Qingbo Liu, Taylor Jumpa, Randal R. Ketchem, Dung Ngoc Pham Nguyen, William David Tolbert, Brian G. Pierce, , Anthony L. DeVico

This study engineers an HIV broadly neutralizing antibody to improve its potency, antiviral activity, and manufacturability while maintaining safety and efficacy.

Structure · May 14, 2025Peer-reviewedBioengineering