Deletion of NuRD component Mta2 in nephron progenitor cells causes developmentally programmed FSGS
Jeannine M. Basta, Lynn Robbins, Lisa Stout, Michelle Brennan, John P. Shapiro, Mary Chen, Darcy R. Denner, Ángel Baldán, Nidia Cordeiro Messias, Sethu M. Madhavan, Samir V. Parikh, Michael I. Rauchman
This study shows that deleting Mta2 in nephron progenitor cells leads to low nephron number, which causes FSGS and CKD through impaired mitochondrial lipid metabolism and gene regulation.
bioRxiv · Oct 18, 2023 · PreprintDevelopmental Biology