Michelle Brennan

Spatial transcriptomics for gene discovery identifies Slc13a5 as a modulator of bone mechanoadaptation

This study uses spatial transcriptomics to identify Slc13a5 as a regulator of bone mechanoadaptation, showing its role in mineralization and resorption under mechanical loading.

Loss of E3 ligase Ube4A disrupts colon homeostasis and accelerates experimental colitis via altered lipid handling

This study shows that loss of Ube4A in mice worsens experimental colitis by disrupting lipid metabolism and increasing inflammation.

BDH1-Dependent Ketone Body Metabolism Maintains Muller Cell Homeostasis and Retinal Function

This study shows that BDH1-dependent ketone metabolism supports Muller cell function and retinal health, with implications for treating retinal diseases.

Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

Loss of mitochondrial pyruvate transport initiates cardiac glycogen accumulation and heart failure

This study shows that loss of the mitochondrial pyruvate carrier in the heart leads to glycogen accumulation and heart failure, which can be reversed by inhibiting glycogen synthesis or a ketogenic diet.

The chromatin landscape of healthy and injured cell types in the human kidney

The paper defines the chromatin landscape of healthy and injured kidney cells using multi-omics data, identifying regulatory elements and transcription factor networks involved in injury response.

Deletion of NuRD component Mta2 in nephron progenitor cells causes developmentally programmed FSGS

This study shows that deleting Mta2 in nephron progenitor cells leads to low nephron number, which causes FSGS and CKD through impaired mitochondrial lipid metabolism and gene regulation.