A phosphorylation-dependent mechanism controls splice variant-specific S-palmitoylation of cardiac Kv4.3
Eleanor Dickson-Murray, Chunyun Du, Chien-Wen S. Kuo, Rebecca J. Gilchrist, Sheon Mary, Samuel Adu, Outi Kämäräinen, Amr Wahdan, Emma Dunning, Fiona Jordan, Elaine Brown, Jack W. Houghton, Daria Berezina, Jianan Lu, Edward W. Tate, , William Fuller
This paper identifies a phosphorylation-dependent mechanism that regulates splice variant-specific S-palmitoylation of Kv4.3, showing how phosphorylation at S538 primes palmitoylation at C546/547 and modulates channel function.
bioRxiv · Jul 6, 2026 · PreprintCell Biology