Author
Imperial College LondonORCID 0000-0002-2971-0271Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Eduardo Alves, Jack W. Houghton, Lindsay B. Stewart, Mufuliat Toyin Famodimu, Rosie Bridgwater, Mariana Reis Wunderlich, Naoki Matoba, Annie Z. Tremp, Michaela Bikarova, Jianan Lu, Mojca Kristan, Colin J. Sutherland, Edward W. Tate, Michael J. Delves
PLoS Pathogens · Sep 23, 2026Peer-reviewedMicrobiology
Elena De Vita, Adam Thomas, Delia Brustur, Montse Tersa, Rita Petracca, Shradda Vadodaria, Deborah A. Briggs, Jack W. Houghton, Thomas Lanyon‐Hogg, Gregory B. Craven, Rhodri M. L. Morgan, Alan Armstrong, David J. Mann, Katharine M. Lodge, Alistair N. Hume, , Edward W. Tate
This paper develops the first cell-active covalent inhibitors of RAB27-effector interactions, showing enantioselectivity and improved potency over a previously reported toxic compound.
Journal of the American Chemical Society · Aug 3, 2026Peer-reviewedBiochemistry
Eleanor Dickson-Murray, Chunyun Du, Chien-Wen S. Kuo, Rebecca J. Gilchrist, Sheon Mary, Samuel Adu, Outi Kämäräinen, Amr Wahdan, Emma Dunning, Fiona Jordan, Elaine Brown, Jack W. Houghton, Daria Berezina, Jianan Lu, Edward W. Tate, , William Fuller
This paper identifies a phosphorylation-dependent mechanism that regulates splice variant-specific S-palmitoylation of Kv4.3, showing how phosphorylation at S538 primes palmitoylation at C546/547 and modulates channel function.
bioRxiv · Jul 6, 2026 · PreprintCell Biology
Matthew T James, Courtney Dane, Karolina Wojtania, Caoimhe McAuley, Andrea Goya Grocin, Remigiusz Adam Serwa, Michael L. Glenn, Erin M P E Getty, Aidan O’Riain, Jack W. Houghton, Aidan Ferris, Sheerien Manzoor, David Courtney, Ultan F. Power, Edward W. Tate, Aurélie Mousnier
This study identifies RUVBL1/2 as a host ATPase essential for rhinovirus replication and shows that its inhibition effectively blocks viral replication without resistance development.
bioRxiv · May 14, 2026 · PreprintMicrobiology
Hannah B. L. Jones, Simeon D. Draganov, Sofia Schönbauer Huamán, Peter A. C. Wing, Chuong Nguyen, Zhu Liang, Julia Dörner, Jasper Lithgow, Emma J. Murphy, Alice Beard, Andrea Pierangelini, Jack W. Houghton, Mackenzie E. Robert, Sarah E. Flannery, Anthony Tumber, , Adán Pinto-Fernández
This paper introduces a high-throughput activity proteomics pipeline for discovering deubiquitinase inhibitors, identifying potent and selective inhibitors with minimal optimization.
bioRxiv · May 27, 2025 · PreprintBiochemistry
Maria M. Shchepinova, Rachel E. Richardson, Jack W. Houghton, Abigail R. Walker, Mohammed Safar, Daniel Conole, Aylin Carla Hanyaloglu, Edward W. Tate
This study uses APEX2 proteomics to map the spatiotemporal interactome of the luteinizing hormone receptor (LHR) and identifies novel interactors like RAP2B that modulate receptor signaling and trafficking.
Cell chemical biology · May 1, 2025Peer-reviewedBiochemistry
Sophia Y. Breusegem, Jack W. Houghton, Raquel Romero-Bueno, Adrián Fragoso-Luna, Katherine A. Kentistou, Ken K. Ong, Anne F. J. Janssen, Nicholas A. Bright, Christian G. Riedel, John R. B. Perry, Peter Askjaer, Delphine Larrieu
A whole genome multiparametric CRISPR screen in progeria identifies new pathways that can reverse cellular aging phenotypes by targeting protein translation and related processes.
Nature Communications · Feb 16, 2025Peer-reviewedMolecular Biology
Cory A. Ocasio, Marc P. Baggelaar, James Sipthorp, Ana Losada de la Lastra, Manuel Tavares, Jana Volarić, Christelle Soudy, Elisabeth M. Storck, Jack W. Houghton, Susana Alejandra Palma-Duran, James I. MacRae, Goran Tomić, Lotte Carr, Julian Downward, Ulrike Eggert, Edward W. Tate
The paper introduces a chemical genetic system to map ZDHHC-specific S-acylation substrates at the whole proteome level in intact cells.
Nature Biotechnology · Jan 8, 2024Peer-reviewedMolecular Biology