SPINK3-sperm interaction determines a stable sperm subpopulation with intact CatSper channel
Anabella R Nicolli, Xiaofang Huang, Lucía Zalazar, Cintia Stival, Lucila R. Gomez-Olivieri, Gianluca Demare, Ana Romarowski, Mariano Gabriel Buffone, Dario Krapf, Jean‐Ju Chung, Andreína Cesari
The paper identifies SPINK3 as a protease inhibitor that prevents CATSPER1 cleavage in sperm, preserving CatSper channel integrity and delaying capacitation.
Journal of Cellular Physiology · Jan 1, 2026Peer-reviewedCell Biology