Jean‐Ju Chung

This study identifies soluble ZP2 N-terminal fragments as activators of CatSper-dependent Ca2+ entry, regulating sperm motility and acrosomal exocytosis in mice and humans.

This study identifies the essential role of CATSPERε extracellular domains in assembling the CatSper channel complex and modulating sperm hyperactivation and fertilization.

The paper identifies SPINK3 as a protease inhibitor that prevents CATSPER1 cleavage in sperm, preserving CatSper channel integrity and delaying capacitation.

This study shows that coordinated CAII and CAIV pH regulation is essential for sperm motility by establishing dual-compartment pH environments that activate CatSper channels.

This study identifies a nuclear role for AGO2 in spermatogenesis, showing it enhances protein expression by interacting with splicing and chromatin factors.