Neutrophils repurpose the nucleolus as a cytokine reservoir and secretory organelle
Shuying Xu, Asya Smirnov, Rachel L. Kinsella, Ananda N. Rankin, Ashley D. Wise, Jessica M. Alexander, Benjamin J. Patty, Sophie M. Mikhail, Rachel M. Bello, Darren Kreamalmeyer, Sebastián Boluarte Baca, Aamir Khan, Benjamin L. Allsup, Sheikh Mahmud, Bryan D. Bryson, , Christina M Stallings
The paper shows neutrophils store and release IFN-I from the nucleolus, revealing a new role for nucleolar stress in immune responses.
bioRxiv · May 21, 2026 · PreprintImmunology