Andrew J. Monteith

Preserving Nanotherapy-Induced Allogeneic Murine Islet Graft Tolerance During Distal Methicillin-Resistant Staphylococcus aureus Skin Infection

This study shows that a nanotherapy (rPS) that induces islet graft tolerance can be compromised by MRSA infection, but combining it with methylprednisolone improves survival.

Efficient colonic colonization by Campylobacter jejuni requires the heme receptor ChuA

This study shows that the heme receptor ChuA is essential for Campylobacter jejuni to efficiently colonize the colon and cause inflammation.

Specific F1 ATP synthase inhibition delivers transient mitochondrial stress for selective targeting of acute myeloid leukemia

This study shows that inhibiting F1 ATP synthase with EB2023 causes transient mitochondrial stress in AML cells, enabling effective treatment without harming healthy tissues.

Neutrophils repurpose the nucleolus as a cytokine reservoir and secretory organelle

The paper shows neutrophils store and release IFN-I from the nucleolus, revealing a new role for nucleolar stress in immune responses.

Reduced late endosome/lysosome function promotes SLE through chronic PI3k activity and SHP-1/SHIP-1 defects

This study identifies reduced late endosome/lysosome function in SLE patients, linked to chronic PI3k activity and SHP-1/SHIP-1 defects, and suggests it as a potential biomarker.

Activation of the Spx redox sensor counters cysteine-driven Fe(II) depletion under disulfide stress

This study shows that the Spx redox switch in S. aureus is critical for managing cysteine levels during disulfide stress, preventing Fe(II) depletion and growth inhibition.

A TLR7/9-IFNα-LDHB axis drives vital NET release and compromises antibacterial defense.

The paper identifies a TLR7/9-IFNα-LDHB axis that impairs NETosis in SLE, leading to bacterial susceptibility, and shows reversal with HCQ and IFNAR blockade.

Efficient gastrointestinal colonization by Campylobacter jejuni requires components of the ChuABCD heme transport system

This study shows that the ChuABCD heme transport system in Campylobacter jejuni is necessary for efficient colonization and pathogenicity, though not fully essential.