Author

Darren Metcalf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Alessia Tagliavini· 2 shared Anna M. UptoniD· 2 shared David J. Hermann· 2 shared Debra Flood· 2 shared Denise FedericoiD· 2 shared Emilie Huc‐Claustre· 2 shared Khisimuzi E. Mdluli· 2 shared Laure Brock· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Alessia Tagliavini

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Nonclinical pharmacokinetics and relative efficacy of the first 25 novel tuberculosis drug combinations from the PAN-TB consortium: Use of the BALB/c relapsing mouse model and combination pharmacokinetics within a modeling-based framework

Sylvie Sordello, Alessia Tagliavini, Xavier Boulenc, Laure Brock, Simone Zannoni, Chiara Roversi, ROBERTO VISENTIN, Darren Metcalf, Denise Federico, Simone Modolo, Giulia Calusi, Roberto Petterlini, Guillaume R. Golovkine, Cécile Pascal, Emilie Huc‐Claustre, , Anna M. Upton

The paper evaluates 25 tuberculosis drug combinations in a mouse model, finding 15 combinations with T90 <5 months and three top combinations curing 90% of mice in <3 months.

bioRxiv · May 7, 2026 · PreprintMicrobiology

A modeling-based framework to evaluate forgiveness of TB drug combinations in a BALB/c relapsing mouse model.

Sylvie Sordello, Laure Brock, Alessia Tagliavini, Denise Federico, Xavier Boulenc, Marco Pergher, Emilie Huc‐Claustre, Darren Metcalf, Nicholas D. Walter, Gregory T. Robertson, James Clary, Alexander K. Berg, Khisimuzi E. Mdluli, David J. Hermann, Debra Flood, Anna M. Upton

This study evaluates the forgiveness of TB drug combinations using a mouse model, finding BPaMZ is more forgiving of missed doses than RHZE/RH.

bioRxiv · Aug 7, 2025 · PreprintPharmacology & Toxicology