Labile iron overload reprograms microglia and neurons for lipid droplet synthesis in the aging brain
Karina Cunha e Rocha, Qian Xiang, Chengjia Qian, Lishuan Wang, Wei Yuan, Varsha Beldona, Ying Duan, Luana Veras, Darya Abolmaali, Garam An, Junho Park, Whasun Lim, Xu Chen, Ying Liang Wei
This study identifies a mitochondrial-iron axis that drives lipid droplet formation in aging microglia and neurons through reactive oxygen species, revealing a microglia-neuron axis regulating iron metabolism.
bioRxiv · Nov 3, 2025 · PreprintImmunology