Addiction-Like Severity Predicts Prolonged Oxycodone Withdrawal-Induced Allodynia in Genetically Diverse Rats
Sonja Lorean Plasil, Lani Tieu, Chengjia Qian, Natalie Taylor, Elizabeth A. Sneddon, Lieselot L. G. Carrette, Molly Brennan, Alex Morgan, Dyar N. Othman, Kathleen Bai, Sara Foroutani, Giordano de Guglielmo, Marsida Kallupi, Olivier George
This study shows that higher addiction-like severity in rats predicts prolonged oxycodone withdrawal-induced allodynia, with stronger associations between self-administration behaviors and pain sensitivity.
bioRxiv · May 18, 2026 · PreprintPharmacology & Toxicology