Evolution of the conformational ensemble and allosteric networks of apoptotic caspases in chordates
Isha Joglekar, Mithun Nag Karadi Giridhar, David A. Diaz, Ankit Deo, A. Clay Clark
This study identifies a conserved allosteric network in apoptotic caspases across chordates, revealing how conformational dynamics and residue interactions regulate their function over 500 million years of evolution.
Biochemical Journal · Jul 23, 2025Peer-reviewedBiochemistry