Mithun Nag Karadi Giridhar

The paper investigates how covalent inhibitors of PPARγ shift its conformational state, affecting ligand binding and inhibitor efficacy.

This study determines the structural properties of full-length IMP2, revealing its dimeric conformation and RNA-induced changes, which may inform drug design.

This study compares FX-909 to other covalent PPARγ inverse agonists, showing improved corepressor-selective inverse agonism and stabilization of a repressive conformation.

This study identifies a conserved allosteric network in apoptotic caspases across chordates, revealing how conformational dynamics and residue interactions regulate their function over 500 million years of evolution.