Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly
Jacopo Amerigo Carpentieri, Amandine Di-Cicco, Maruša Lampič, David Andreau, Laurence Del Maestro, Fatima El Marjou, Laure Coquand, Nadia Bahi‐Buisson, Jean‐Baptiste Brault, Alexandre D. Baffet
This study shows that WDR81 loss of function disrupts endosomal trafficking of EGFR, reduces MAP kinase activation, and causes microcephaly by impairing radial glial progenitor proliferation.
Nature Communications · Jan 10, 2022Peer-reviewedNeuroscience