Author

Laurence Del Maestro

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3 Cell Biology· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Slimane Ait‐Si‐AliiD· 5 shared Guillaume VelascoiD· 3 shared Ekaterina BoyarchukiD· 2 shared Roberta Rapone· 2 shared Véronique Joliot· 2 shared Adeline Humbert· 1 shared Adrián Gabriel TorresiD· 1 shared Agathe SubtiliD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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5 shared papersMolecular Biology

Slimane Ait‐Si‐AliORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Intracellular growth of Chlamydia trachomatis leads to global histone hypermethylation by impairing demethylation

Chloé I. Charendoff, Félix V. Louchez, Yongzheng Wu, Lee Dolat, Guillaume Velasco, Stéphanie Perrinet, Adrián Gabriel Torres, Laure Blanchet, Magalie Duchateau, Quentin Giai Gianetto, Mariette Matondo, Laurence Del Maestro, Slimane Ait‐Si‐Ali, Frédéric Bonhomme, Gaël A. Millot, , Agathe Subtil

This study shows that Chlamydia trachomatis infection causes global histone hypermethylation by inhibiting demethylation, leading to altered transcription and affecting infection outcomes.

eLife · Sep 14, 2026Peer-reviewedCell Biology

Epigenetic control of nuclear mechanics and cellular migration via histone H3 lysine 9 methylation at Lamina-Associated Domains

Silvia Comunian, Valentin Petit, Guillaume Velasco, Vlada Zakharova, Cécile Jebane, Pauline Lahure, Véronique Joliot, Laurence Del Maestro, Magali Hennion, Guillaume Lamour, Jean‐Baptiste Manneville, Emmanuèle Helfer, Ekaterina Boyarchuk, Slimane Ait‐Si‐Ali

This study shows that SETDB1 regulates LADs and nuclear mechanics by modulating H3K9me3, affecting cancer cell migration without major transcriptional changes.

bioRxiv · Nov 28, 2025 · PreprintMolecular Biology

Automethylation of lysine methyltransferase SETDB1 on H3K9-like motifs regulates interactions with chromodomain proteins and controls its functions

Paola Cruz‐Tapias, Guillaume Velasco, Roberta Rapone, Laurence Del Maestro, Victor Cochard, Guillaume Chevreux, Véronique Joliot, Ekaterina Boyarchuk, Slimane Ait‐Si‐Ali

This study shows that SETDB1 automethylation on H3K9-like motifs is essential for its function in ESCs, affecting chromodomain interactions and H3K9me3 establishment.

bioRxiv · Oct 22, 2025 · PreprintMolecular Biology

Glucose controls co-translation of structurally related mRNAs via the mTOR and eIF2 pathways in human pancreatic beta cells

Manuel Bulfoni, Costas Bouyioukos, Albatoul Zakaria, Fabienne Nigon, Roberta Rapone, Laurence Del Maestro, Slimane Ait‐Si‐Ali, Raphaël Scharfmann, Bertrand Cosson

This study shows glucose induces translational regulation of over 400 mRNAs in human pancreatic beta cells via mTOR and eIF2 pathways, independent of transcriptional changes.

Frontiers in Endocrinology · Aug 5, 2022Peer-reviewedGenomics

Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly

Jacopo Amerigo Carpentieri, Amandine Di-Cicco, Maruša Lampič, David Andreau, Laurence Del Maestro, Fatima El Marjou, Laure Coquand, Nadia Bahi‐Buisson, Jean‐Baptiste Brault, Alexandre D. Baffet

This study shows that WDR81 loss of function disrupts endosomal trafficking of EGFR, reduces MAP kinase activation, and causes microcephaly by impairing radial glial progenitor proliferation.

Nature Communications · Jan 10, 2022Peer-reviewedNeuroscience

Paramecium Polycomb Repressive Complex 2 physically interacts with the small RNA binding PIWI protein to repress transposable elements

Caridad Miró-Pina, Takayuki Kawaguchi, Olivia Charmant, Audrey Michaud, Isadora S. Cohen, Adeline Humbert, Yan Jaszczyszyn, Laurence Del Maestro, Daniel Holoch, Slimane Ait‐Si‐Ali, Olivier Arnaiz, Raphaël Margueron, Sandra Duharcourt

The paper identifies PRC2 cofactors that mediate small RNA recruitment to repress transposable elements in Paramecium.

bioRxiv · Aug 12, 2021 · PreprintMolecular Biology