Alexandre D. Baffet

This paper identifies the human-specific gene FRMPD2B as an activity- and experience-regulated modifier of cortical connectivity, showing its role in postnatal brain development.

This study develops a 2D system to generate human basal radial glia from iPSCs, showing they exhibit key molecular and functional features of native cells.

The paper identifies phosphorylation of NEUROGENIN2 as a regulator of human radial glial cell neuronal output, leading to increased production of upper-layer neurons.

The paper identifies two translocation modes for human fetal neural stem cells, showing that interphasic somal translocation (IST) accounts for 85% of their movement during cortical colonization.

This study shows that lamin protein levels correlate with glioblastoma aggressiveness, affecting nuclear mechanics and cell behavior.

The paper maps cell fate decisions in human developing neocortex progenitors, showing abundant direct neurogenesis bypassing intermediate progenitors.

This study shows that WDR81 loss of function disrupts endosomal trafficking of EGFR, reduces MAP kinase activation, and causes microcephaly by impairing radial glial progenitor proliferation.