Genomic MET amplification occurs early in NF1-related malignant peripheral nerve sheath tumor (MPNST) progression and is a potent therapeutic target
Jacqueline D. Peacock, Matthew G. Pridgeon, Elizabeth A. Tovar, Curt J. Essenburg, Megan Bowman, Zachary Madaj, Julie Koeman, Jamie Grit, Rebecca D. Dodd, Diana M. Cardona, Mark Chen, David G. Kirsch, Flavio Maina, Rosanna Dono, Mary E. Winn, , Matthew R. Steensma
This study identifies early MET amplification in NF1-related MPNST progression and shows MET inhibition effectively targets these tumors.
bioRxiv · Oct 5, 2017 · PreprintCancer Biology