Oncogenic RAS-MET signal interactions are modulated by P53 status in NF1-related MPNSTs
Matthew G. Pridgeon, Elizabeth A. Tovar, Curt J. Essenburg, Zachary Madaj, Elissa A. Boguslawski, Patrick S. Dischinger, Jacqueline D. Peacock, Flavio Maina, Rosanna Dono, Mary E. Winn, Carrie R. Graveel, Matthew R. Steensma
This study shows that P53 status modulates the response to MET and MEK inhibition in NF1-related MPNSTs, with P53 wild-type tumors showing greater suppression of RAS/MAPK and PI3K/AKT activation.
bioRxiv · Oct 5, 2017 · PreprintCancer Biology