Peptide-based GIP receptor inhibition produces limited metabolic improvements in mice whether alone or combined with GLP-1 agonism.
Jason A. West, Soumitra S. Ghosh, David G. Parkes, Anastasia Tsakmaki, Rikke Veggerby Grønlund, Philip J. Pedersen, DAVID G. MAGGS, Harith Rajagopalan, Gavin A. Bewick
This study evaluates the metabolic effects of peptide-based GIP receptor antagonists alone or combined with GLP-1 agonism in mice, finding limited benefits from antagonists alone but some synergistic effects when combined with GLP-1.
bioRxiv · Oct 29, 2019 · PreprintPhysiology