Gavin A. Bewick

Neuropeptide Y4 receptor activation delays autoimmune diabetes by reprogramming β-cell stress and immune tolerance

This study shows that activating the Y4R receptor protects β-cells and modulates islet immunity, delaying autoimmune diabetes in multiple models.

Vitamin D receptor is necessary for metabolic health after sleeve gastrectomy

This study shows that the vitamin D receptor is essential for metabolic health after sleeve gastrectomy in mice, affecting insulin sensitivity, white adipose tissue function, and inflammation, with similar findings in human patients.

The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis by enhancing GLP-1 secretion and L-cell differentiation

This paper shows indole, a gut microbial metabolite, improves glucose control by boosting GLP-1 secretion and L-cell differentiation in mice, suggesting it could be used as a therapeutic for type 2 diabetes.

Extracellular Ca2+-Sensing Receptor (CaSR) Regulates Hypothalamic Function to Control Energy and Skeletal Metabolism in Mice

This study shows that neuronal CaSR regulates energy and skeletal metabolism by modulating hypothalamic function in mice, affecting growth, bone mass, and metabolic parameters.

NodoMap: a spatio-cellular map of the mouse nodose ganglia

The paper creates a spatio-cellular map of the mouse nodose ganglia using single nucleus RNA sequencing and spatial transcriptomics, revealing subtype-specific gene expression and spatial organization.

Measurement of Real Time Serotonin Dynamics from Human Derived Gut Organoids

This study measures real-time serotonin dynamics in human-derived gut organoids using fast-scan cyclic voltammetry, showing increased release events after forskolin and IBMX stimulation.

NAMPT activity plays a key role in driving autoimmune processes that characterize type 1 diabetes development in mice

This study shows that inhibiting NAMPT reduces inflammation and beta-cell damage in T1D by blocking cytokine-mediated immune responses in mice.

Mapping the druggable targets displayed by human colonic enteroendocrine cells

The paper identifies and catalogs druggable targets in human colonic enteroendocrine cells using bulk and single-cell RNA sequencing, and functionally validates two novel receptors.

Dissecting Functional, Structural, and Molecular Requirements for Serotonin Release from Mouse Enterochromaffin Cells

The paper investigates serotonin release mechanisms from mouse enterochromaffin cells using multiple techniques and finds that serotonin is primarily released from large dense-core vesicles with slow kinetics, similar to other endocrine cells.

Peptide-based GIP receptor inhibition produces limited metabolic improvements in mice whether alone or combined with GLP-1 agonism.

This study evaluates the metabolic effects of peptide-based GIP receptor antagonists alone or combined with GLP-1 agonism in mice, finding limited benefits from antagonists alone but some synergistic effects when combined with GLP-1.