Lung Epithelial TLR7 is a Factor in Viral Replication and Pathogenesis
Madison J. Granoski, Ryley D. McClelland, Leanne M. Bilawchuk, Stephanie Hindle, Joaquin Lopez-Orozco, Quinten Kieser, Lionel D. Jensen, Cameron D. Griffiths, Farah Elawar, Olivier J Julien, Deanna M. Santer, Carola G. Vinuesa, Tom C. Hobman, Craig N. Jenne, David J. Marchant
This study shows that TLR7 in lung epithelial cells drives RSV and influenza replication and disease, but not HPIV3, and links TLR7 expression to sex differences in viral disease.
bioRxiv · Nov 4, 2026 · PreprintMicrobiology